2 attackers go to the opposite end line in a 2v2.
Give them 2-3 minutes to get enough reps in, but they will tire quickly, so be mindful. Switch teams around at the end of the 2-3 minutes and let the attackers defend and vice versa. After that, you can switch groups between zones.
The 2v2 is an excellent progression and representation of a full game. It has all four moments of the game: attacking, defending, and transitioning between attacking>defending and defending>attacking.
Small-sided games like this offer so much to be learned about the game, with more reps for players and more opportunities for success and learning.